Dr Girisha is heading the Department of Medical Genetics at Kasturba Medical College, Manipal which he established at Manipal Academy of Higher Education, Manipal. He is a clinician with special interest in skeletal dysplasia and prenatal and postnatal dysmorphology. His research is focused on skeletal dysplasia and he is a member of International Society for Skeletal Dysplasia where he serves as a member of nosology group. He is a founding member and now secretary of Indian Academy of Medical Genetics. He also serves as an associate editor for American Journal of Medical Genetics and is an editorial board member for Journal of Human Genetics.

Over the last two decades, his team played a critical role in the growth of medical genetics as a specialty in India in education, patient care and research (184 peer-reviewed publications and contributing to discovery of at least fifteen new diseases and their genetic bases). He is the principal investigator for 10 research projects. He is passionate about transforming human lives through application of genomic technologies for prevention, diagnosis and care. His team established the first university approved Master of Science program in Genetic Counseling in India. Four scholars have completed PhD under his supervision and he is currently guiding six PhD students.

He is a medical graduate (MBBS) from Government Medical College, Mysore with post-graduation (MD) in Pediatrics from Seth GS Medical College, Mumbai. He is trained in medical genetics (DM) from Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow. He was a fellow at Cedar Sinai Medical Center, Los Angeles for training in skeletal dysplasia.

He is also an entrepreneur and is promoting Suma Genomics Private Limited.